Altren^® (Altrenogest) is contraindicated for use in mares having a previous or current history of uterine inflammation. Natural or synthetic gestagen therapy may exacerbate existing low-grade or “smoldering” uterine inflammation into a fulminating uterine infection in some instances. Do not use in horses intended for human consumption.

WARNINGS: Skin contact must be avoided; protective gloves must be worn when handling this product. Not for use in humans. Keep out of reach of children. Altren^® is absorbed through unbroken skin, and exposure may result in serious side effects to both women and men. Wear vinyl, neoprene, or nitrile gloves when handling or administering Altren^® (Altrenogest), or when touching contaminated surfaces or equipment. Latex gloves are not protective.

PREGNANT WOMEN OR WOMEN WHO MAY BE PREGNANT SHOULD NOT HANDLE ALTREN^®. WOMEN OF CHILDBEARING AGE SHOULD EXERCISE EXTREME CAUTION WHEN HANDLING THIS PRODUCT.

Altren^® (Altrenogest) is readily absorbed through the skin and could lead to a disruption of the menstrual cycle or prolongation of pregnancy. People who should not handle this product include those with blood clots or clotting disorders, or with a history of these events, suspected estrogen-dependent neoplasia, benign or malignant tumors which developed during the use of oral contraceptives or other estrogen containing products, liver dysfunction or disease, and women with known or suspected carcinoma of the breast or undiagnosed vaginal bleeding. Accidental spillage on the skin should be washed off immediately with soap and water. Keep out of the reach of children. For complete safety information, refer to the package insert.

PRECAUTIONS: Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia.

For complete safety information, refer to the package insert.